The Nem1/Spo7-Pah1/lipin axis is required for autophagy induction after TORC1 inactivation.
Identifieur interne : 000462 ( Main/Exploration ); précédent : 000461; suivant : 000463The Nem1/Spo7-Pah1/lipin axis is required for autophagy induction after TORC1 inactivation.
Auteurs : Muhammad Arifur Rahman [Japon] ; Md Golam Mostofa [Japon] ; Takashi Ushimaru [Japon]Source :
- The FEBS journal [ 1742-4658 ] ; 2018.
Descripteurs français
- KwdFr :
- Autophagie (physiologie), Azote (métabolisme), Facteurs de transcription (antagonistes et inhibiteurs), Mitochondries (métabolisme), Noyau de la cellule (métabolisme), Phosphatidate phosphatase (métabolisme), Protéines de Saccharomyces cerevisiae (antagonistes et inhibiteurs), Protéines de Saccharomyces cerevisiae (métabolisme), Protéines de Saccharomyces cerevisiae (physiologie), Saccharomyces cerevisiae (métabolisme).
- MESH :
- antagonistes et inhibiteurs : Facteurs de transcription, Protéines de Saccharomyces cerevisiae.
- métabolisme : Azote, Mitochondries, Noyau de la cellule, Phosphatidate phosphatase, Protéines de Saccharomyces cerevisiae, Saccharomyces cerevisiae.
- physiologie : Autophagie, Protéines de Saccharomyces cerevisiae.
English descriptors
- KwdEn :
- Autophagy (physiology), Cell Nucleus (metabolism), Mitochondria (metabolism), Nitrogen (metabolism), Phosphatidate Phosphatase (metabolism), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (antagonists & inhibitors), Saccharomyces cerevisiae Proteins (metabolism), Saccharomyces cerevisiae Proteins (physiology), Transcription Factors (antagonists & inhibitors).
- MESH :
- chemical , antagonists & inhibitors : Saccharomyces cerevisiae Proteins, Transcription Factors.
- chemical , metabolism : Nitrogen, Phosphatidate Phosphatase, Saccharomyces cerevisiae Proteins.
- metabolism : Cell Nucleus, Mitochondria, Saccharomyces cerevisiae.
- physiology : Autophagy, Saccharomyces cerevisiae Proteins.
Abstract
Autophagy is a process that requires intense membrane remodeling and consumption. The nutrient-responsive TORC1 (target of rapamycin complex 1) kinase regulates autophagy. However, how TORC1 controls autophagy via lipid/membrane biogenesis is unknown. TORC1 regulates the function of yeast phosphatidate phosphatase lipin Pah1 via the Nem1/Spo7 phosphatase complex. Here, we show that the Nem1/Spo7-Pah1 axis is required for autophagy induction after TORC1 inactivation and survival during starvation. Furthermore, this axis was critical for nucleophagy (both micronucleophagy and macronucleophagy) and was required for proper localization of micronucleophagy factor Nvj1 and macronucleophagy receptor Atg39. This study indicated that the Nem1/Spo7-Pah1 axis controlled by TORC1 is a critical branch for autophagy induction in nutrient starvation conditions.
DOI: 10.1111/febs.14448
PubMed: 29604183
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Ushimaru</name><affiliation wicri:level="1"><nlm:affiliation>Graduate School of Science and Technology, Shizuoka University, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Graduate School of Science and Technology, Shizuoka University</wicri:regionArea><wicri:noRegion>Shizuoka University</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University</wicri:regionArea><wicri:noRegion>Shizuoka University</wicri:noRegion></affiliation></author></analytic><series><title level="j">The FEBS journal</title><idno type="eISSN">1742-4658</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autophagy (physiology)</term><term>Cell Nucleus (metabolism)</term><term>Mitochondria (metabolism)</term><term>Nitrogen (metabolism)</term><term>Phosphatidate Phosphatase (metabolism)</term><term>Saccharomyces cerevisiae (metabolism)</term><term>Saccharomyces cerevisiae Proteins (antagonists & inhibitors)</term><term>Saccharomyces cerevisiae Proteins (metabolism)</term><term>Saccharomyces cerevisiae Proteins (physiology)</term><term>Transcription Factors (antagonists & inhibitors)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Autophagie (physiologie)</term><term>Azote (métabolisme)</term><term>Facteurs de transcription (antagonistes et inhibiteurs)</term><term>Mitochondries (métabolisme)</term><term>Noyau de la cellule (métabolisme)</term><term>Phosphatidate phosphatase (métabolisme)</term><term>Protéines de Saccharomyces cerevisiae (antagonistes et inhibiteurs)</term><term>Protéines de Saccharomyces cerevisiae (métabolisme)</term><term>Protéines de Saccharomyces cerevisiae (physiologie)</term><term>Saccharomyces cerevisiae (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Saccharomyces cerevisiae Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Nitrogen</term><term>Phosphatidate Phosphatase</term><term>Saccharomyces cerevisiae Proteins</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Facteurs de transcription</term><term>Protéines de Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Nucleus</term><term>Mitochondria</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Azote</term><term>Mitochondries</term><term>Noyau de la cellule</term><term>Phosphatidate phosphatase</term><term>Protéines de Saccharomyces cerevisiae</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Autophagie</term><term>Protéines de Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Autophagy</term><term>Saccharomyces cerevisiae Proteins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Autophagy is a process that requires intense membrane remodeling and consumption. The nutrient-responsive TORC1 (target of rapamycin complex 1) kinase regulates autophagy. However, how TORC1 controls autophagy via lipid/membrane biogenesis is unknown. TORC1 regulates the function of yeast phosphatidate phosphatase lipin Pah1 via the Nem1/Spo7 phosphatase complex. Here, we show that the Nem1/Spo7-Pah1 axis is required for autophagy induction after TORC1 inactivation and survival during starvation. Furthermore, this axis was critical for nucleophagy (both micronucleophagy and macronucleophagy) and was required for proper localization of micronucleophagy factor Nvj1 and macronucleophagy receptor Atg39. This study indicated that the Nem1/Spo7-Pah1 axis controlled by TORC1 is a critical branch for autophagy induction in nutrient starvation conditions.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29604183</PMID><DateCompleted><Year>2019</Year><Month>03</Month><Day>14</Day></DateCompleted><DateRevised><Year>2019</Year><Month>03</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1742-4658</ISSN><JournalIssue CitedMedium="Internet"><Volume>285</Volume><Issue>10</Issue><PubDate><Year>2018</Year><Month>05</Month></PubDate></JournalIssue><Title>The FEBS journal</Title><ISOAbbreviation>FEBS J</ISOAbbreviation></Journal><ArticleTitle>The Nem1/Spo7-Pah1/lipin axis is required for autophagy induction after TORC1 inactivation.</ArticleTitle><Pagination><MedlinePgn>1840-1860</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/febs.14448</ELocationID><Abstract><AbstractText>Autophagy is a process that requires intense membrane remodeling and consumption. The nutrient-responsive TORC1 (target of rapamycin complex 1) kinase regulates autophagy. However, how TORC1 controls autophagy via lipid/membrane biogenesis is unknown. TORC1 regulates the function of yeast phosphatidate phosphatase lipin Pah1 via the Nem1/Spo7 phosphatase complex. Here, we show that the Nem1/Spo7-Pah1 axis is required for autophagy induction after TORC1 inactivation and survival during starvation. Furthermore, this axis was critical for nucleophagy (both micronucleophagy and macronucleophagy) and was required for proper localization of micronucleophagy factor Nvj1 and macronucleophagy receptor Atg39. This study indicated that the Nem1/Spo7-Pah1 axis controlled by TORC1 is a critical branch for autophagy induction in nutrient starvation conditions.</AbstractText><CopyrightInformation>© 2018 Federation of European Biochemical Societies.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rahman</LastName><ForeName>Muhammad Arifur</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Graduate School of Science and Technology, Shizuoka University, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mostofa</LastName><ForeName>Md Golam</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Graduate School of Science and Technology, Shizuoka University, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ushimaru</LastName><ForeName>Takashi</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Graduate School of Science and Technology, Shizuoka University, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Japan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>04</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>FEBS J</MedlineTA><NlmUniqueID>101229646</NlmUniqueID><ISSNLinking>1742-464X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C561842">TORC1 protein complex, S 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sortKey="Ushimaru, Takashi" sort="Ushimaru, Takashi" uniqKey="Ushimaru T" first="Takashi" last="Ushimaru">Takashi Ushimaru</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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